Lateral hypothalamic activity indicates hunger and satiety states in humans

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Lateral hypothalamic activity indicates hunger and satiety states in humans

Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader-Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food-related cues induced an increase in beta/low-gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha-frequency DBS prior t...

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Differential effects of hunger and satiety on insular cortex and hypothalamic functional connectivity

The insula cortex and hypothalamus are implicated in eating behaviour, and contain receptor sites for peptides and hormones controlling energy balance. The insula encompasses multi-functional subregions, which display differential anatomical and functional connectivities with the rest of the brain. This study aimed to analyse the effect of fasting and satiation on the functional connectivity pr...

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Hunger and satiety: one brain for two?

UNDERSTANDING THE PHYSIOLOGICAL controls of eating and developing effective pharmacological tools to reduce eating has never been more important. The modern world faces an unprecedented obesity epidemic, and the current treatment strategies are rather unsuccessful. One possible solution may be a combination or cocktail therapy. Obesity control research has been more focused on “long-term” adipo...

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Hunger and Satiety Gauge Reward Sensitivity

Many of the neurocircuits and hormones known to underlie the sensations of hunger and satiety also substantially alter the activity of the dopaminergic reward system. Much interest lies in the ways that hunger, satiety, and reward tie together, as the epidemic of obesity seems tied to the recent development and mass availability of highly palatable foods. In this review, we will first discuss t...

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Neural Control of Hunger, Appetite, and Satiety **

Hunger, appetite, and satiety are often regarded as problems in the physiology of digestion. In recent years, however, they have been studied more and more commonly as functions of the brain. This latter point of view, i.e., neurophysiology, is used in the paper which follows, and the regulation of food intake is here described in terms of mechanisms and reactions that characterize the nervous ...

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ژورنال

عنوان ژورنال: Annals of Clinical and Translational Neurology

سال: 2017

ISSN: 2328-9503

DOI: 10.1002/acn3.466